Publications: 2003-2007

2003

• Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD. Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. J Clin Invest, 2003, 111(10):1547-1554.
• Narayan S, Hawley N, Giguere P, Badley AD. Attenuated T-lymphocyte response to HIV therapy in individuals receiving HMG-CoA reductase inhibitors. HIV Clinical Trials, 2003, 4(3):164-169.
• Badley AD, Roumier T, Lum JJ, and Kroemer G. Mitochondrial apoptosis in HIV-1 infection. Trends in Pharmacol Sci, 2003, 24(6):298-305.
• Lum JJ and Badley AD. Resistance to apoptosis: mechanism for the development of HIV reservoirs. Current HIV Research, 2003, 1:261-274.
• Jiang JQ, Balasubramanian S, Hawley-Foss NC, Badley AD, Rosenthal KL, Copeland KF. Production of CD8+ T cell nonlytic suppressive factors by CD28, CD38, and HLA-DR subpopulations. AIDS Res Hum Retroviruses, 2003; 19(6):497-502.

2004

• Cooper CL, Phenix B, Mbisa G, Lum JJ, Parato K, Hawley-Foss N, Angel JB, Badley AD. Antiretroviral therapy influences cellular susceptibility to apoptosis in vivo. Frontiers in Bioscience, 2004, 9:338-341.
• Buenz EJ, Weaver JG, Bauer BA, Chalpin SD, Badley AD. Cordyceps sinensis extracts do not prevent Fas-receptor and hydrogen peroxide induced T-cell apoptosis. J Ethnopharmacol, 2004, 90:57-62.
• Owen C, Kazim F, and Badley AD. Effect on CD4 T cell count of replacing protease inhibitors in patients with successful HIV suppression: A metaanalysis. AIDS, 2004, 18(4):693-695.
• Cohen I, Boya P, Zhao L, Metivier D, Andreau K, Perfettini JL, Weaver JG, Badley A, Taylor EW, Kroemer G. Anti-apoptotic activity of the glutathione peroxidase homologue encoded by HIV-1. Apoptosis, 2004, Mar, 9(2):181-192.
• Lum JJ, Schnepple DJ, Nie Z, Sanchez-Dardon J, Mbisa GL, Mihowich J, Hawley N, Narayan S, Kim JE, Lynch DH, Badley AD. Differential effects of Interleukin-7 and Interleukin-15 on NK cell anti-Human Immunodeficiency Virus activity. J Virol, 2004, 78:6033-6042.
• Zhang X, Lalezari JP, Badley AD, Dorr A, Kolis SJ, Kinchelow T, and Patel IH. Assessment of metabolic interaction potential of enfuvirtide in HIV-1 infected patients. Clin Pharmacol and Therapeutics J, June 2004, 75(6):558-68.
• Weaver JGR, Rouse MS, Steckelberg JM, Badley AD. Improved survival in experimental sepsis with an orally administered inhibitor of apoptosis. The FASEB Journal, August 2004, 18:1185-1191.
• Buenz EJ, Badley AD. Impact of mitochondrial regulation of apoptosis on the pathogenesis and treatment of HIV-1 induced immunodeficiency. Mitochondrion, 2004, 4:235-254.

2005

• Anson BD, Weaver JGR, Ackerman MJ, Akinsete O, Henry K, January CT, Badley AD. Blockade of HERG channels by HIV protease inhibitors: A possible cause of QT interval prolongation and torsade de pointes. Lancet, 2005, 365:682-686.
• Weaver JG, Tarze A, Moffat TC, LeBras M, Deniaud A, Brenner C, Bren GD, Morin MY, Phenix BN, Dong L, Jiang SX, Sim VL, Zurakowski B, Lallier, J, Hardin H Wettstein, P, van Heeswijk RPG, Douen A, Kroemer RT, Miller B, Hou ST, Bennett SAL, Lynch DH, Kroemer G, Badley AD. Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor. J Clin Invest, 2005, 115(7):1828-1837.
• Weaver JGR, McGregor CGA, Tazelaar HD, Badley AD. Rejection severity directly correlates with myocyte apoptosis in pig-to-baboon cardiac xenotransplantation. J Heart and Lung Transpl, 2005, 24(7):841-847.
• Cuerrier D, Nie Z, Badley AD, Davies PL. Ritonavir does not inhibit calpain in vivo. Biochem and Biophy Res Communications, 2005, Feb 4; 327(1):208-211.
• Badley AD. In vitro and in vivo effects of HIV protease inhibitors on apoptosis. Cell Death & Differentiation, 2005, 12:924-931.
• Lum JJ, Bren G, McClure R, Badley AD. Elimination of senescent neutrophils by TRAIL. J Immunol, 2005, 175:1232-1238.
• Lum JJ, Schnepple DJ, Badley AD. Acquired T cell sensitivity to TRAIL mediated killing during HIV infection is regulated by CXCR4/gp120 interactions. AIDS, 2005, 19(11):1125-1133.
• Trushin SA, Bren GD, Asin S, Paya CV, Badley AD. HIV reactivation by phorbol esters or TCR ligation requires both PKCα and PKCθ. J Virol, 2005, 79(15):9821-9830.
• Graham DB, Bell MP, Huntoon CJ, Weaver JGR, Hawley N, Badley AD, McKean DJ. Increased thymic output in HIV negative patients after antiretroviral therapy. AIDS 2005 Sept 23, 19(14):1467-1472.
• Pittock ST, Norby SM, Grande JP, Croatt AJ, Bren GD, Badley AD, Caplice NM, Griffin MD, Nath KA. MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates. Kidney Int. 2005 Aug 68(2):611-22.

2006

• Roumier T, Szabadkai G, Simoni AM, Perfettini JL, Paulau AL, Castedo M, Metivier D, Badley AD, Rizzuto R, Kroemer G. 1HIV-1 protease inhibitors and cytomegalovirus vMIA induce mitochondrial fragmentation without triggering apoptosis. Cell Death Differ, 2006 13;348-351.
• Vlahakis SR and Badley AD. Influence of proteasome inhibitors on apoptosis. Curr Opin. Clin Nutri Metabol Care, 2006; 9(1):42-47.
• Badley, AD. Identification of TRAIL/APO2L as a novel therapy targeting HIV reservoirs. Journal of Acquired Immune Deficiency Syndromes, 2006; 42(3): S14-S15.
• Assi MA, Binnicker MJ, Wengenack NL, Deziel PJ, Badley AD. Disseminated coccidioidomycosis in a liver transplant recipient with negative serology: use of polymerase chain reaction. Liver Transplantation, 2006; 12:1290-1292.
• Chui C, Cheung PK, Brumme CJ, Mo T, Brumme ZL, Montaner JSG, Badley AD, Harrigan PR. HIV VprR77Q mutation does not influence clinical response of individuals initiating highly active antiretroviral therapy. AIDS Research and Human Retroviruses, 2006; 22(7):615-618.

2007

• O'Hara S P, Small A, Nelson JB, Badley AD, Chen XM, Gores GJ, LaRusso NF. HIV-1 Tat Protein Enhances Cryptosporidium parvum -induced Apoptosis in Cholangiocytes via a Fas Ligand-dependent Mechanism. Infect Immum, 2007; 75: 684-696.
• Murali NS, Ackerman AW, Croatt AJ, Cheng J, Grande JP, Sutor SL, Bram RJ, Bren GD, Badley AD, Alam J, Nath KA. Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: implications for chronic kidney disease. Am J Physiol Renal Physiol, 2007; 292:F837-F844.
• Trushin SA, Algeciras-Schimnich A, Vlahakis SR, Bren GD, Warren S, Schnepple DJ, Badley AD. Glycoprotein 120 binding to CXCR4 causes p38-dependent primary T cell death that is facilitated by, but does not require cell-associated CD4. J Immunol, 2007, 178(8):4846-4853.
• Tracz MJ, Juncos JP, Grrande JP, Croatt AJ, Ackerman AW, Rajagopalan G, Knutson KL, Badley AD, Griffin MD, Alam J, and Nath KA. Renal hemodynamic, inflammatory, and apoptotic responses to lipopolysaccharide in HO-1-/- mice. Am J Pathol, 2007; 170(6), in press.
• Vlahakis SR and Badley AD. HIV Protease Inhibitors. Medicinal Chemistry, 2007, in press.
• Vlahakis SR, Bennet S, Whitehead S, Badley AD. HIV protease inhibitors modulate apoptosis signaling in vitro and in vivo. Apoptosis, 2007, in press.
• Vlahakis SR, Bren GD, Algeciras-Schimnich A, Trushin SA, Schnepple DJ, Badley AD. Flying in the face of resistance: antiviral independent benefit of HIV protease inhibitors on T cell survival. Clin Pharmacol and Therapeutics, 2007, in press.
• Nie Z, Bren GD, Vlahakis SR, Algeciras Schimnich A, Brenchley JM, Trushin SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC, Badley AD. HIV-1 protease cleaves procaspase 8 in vivo. J Virol, 2007, in press.

Published Book Chapters

• Schlech W, Chase D, Badley AD. Development of an oral model of Listeria monocytogenes infections. In: Courtieu AL, Espaze EP, Reynaud AE (Editors). Listeriosis 1985-86, Nantes, pp. 155-160.
• Badley AD, Paya CV. Cytomegalovirus. In: Roizen M, Fleisher L (Editors). Essence of Anesthesia Practice. W.B. Saunders 1997, pp. 100-101.
• Badley AD, Dockrell DH, Paya CV. Apoptosis in AIDS. In: Kaufmann Scott H. (Ed.) Apoptosis: pharmacological implications and therapeutic opportunities. Academic Press 1997, pp. 271-294.
• Lum JJ, Badley AD. Pathogenic Role of Apoptosis in HIV Diseases. Harrisonís Online. December 2000.
• Badley AD, Steckelberg JM. Sepsis Syndrome. In Wilson W, Sande M. (Editors) Current Diagnosis and Treatment in Infectious Diseases. McGraw-Hill 2001, pp. 231-239.
• Badley AD, Steckelberg JM. Cestode Infections. In Wilson W, Sande M. (Editors) Current Diagnosis and Treatment in Infectious Diseases. McGraw-Hill 2001, pp. 863-871.
• Badley AD, Paya CV. Cytomegalovirus. In: Roizen M, Fleisher L (Editors). Essence of Anesthesia Practice. 2nd Edition. W.B. Saunders 2002, pp. 105.
• Lum J, Badley AD. Vpr. In: Cell Death During HIV Infection. Badley AD (Editor), Taylor and Francis Press, Boca Raton, FL 2006, pp. 109-126.
• Nie Z, McNamara D, Badley AD. HIV Protease and Cell Death. In: Cell Death During HIV Infection. Badley AD (Editor), Taylor and Francis Press, Boca Raton, FL 2006, pp 155-168.
• Warren S, Chen X-M, LaRusso NF, Badley AD. Apoptosis as a Pathogenic Mechanism of HIV-Associated Opportunistic Infection. In: Cell Death During HIV Infection. Badley AD (Editor), Taylor and Francis Press, Boca Raton, FL 2006, pp 421-437.
• Schnepple D, Badley AD. Direct Effects of Anti-HIV Therapeutics on Apoptosis. In: Cell Death During HIV Infection. Badley AD (Editor), Taylor and Francis Press, Boca Raton, FL 2006, pp 441-455.
• Weaver JGR, Badley AD. Sepsis Syndrome. In: Current Diagnosis and Treatment in Infectious Diseases. Wilson WR, Sande M (Editors). 2nd Edition. McGraw-Hill 2005, in press.
• Badley AD. Tularemia. In: Pandemic - Point-of Care Pocket Guide. Farmer JC, Badley AD, Poland GA (Editors). Joint Commission Resources, Oakbrook Terrace, IL 2007, pp 61-63.
• Shepard BD, Badley AD. Ricin Toxin. In: Pandemic - Point-of Care Pocket Guide. Farmer JC, Badley AD, Poland GA (Editors). Joint Commission Resources, Oakbrook Terrace, IL 2007, pp 71-73.
• Badley AD. Sepsis Syndrome. In: Infectious Diseases Board Review. Temesgen Z. (Editor).