Self Assembled Monolayer Films of Phosphonates' (Samp) as Platform for the Arg-Gly-Asp (Rgd) Coating

Principal Investigator: Jean D. Sibonga, Ph.D.
Project Coordinator: Mark E. Zobitz — zobitz.mark@mayo.edu

Bioactive coatings as means to improve osseointegration of orthopaedic and dental implants offer great potential. A novel platform of self assembled monolayer films of phosphonates (SAMP) has been developed to bond the RGD-amino-acid sequence, an adhesion domain and intracellular signaling trigger widespread in the extracellular matrix, to titanium implant surface. We used a rat animal model to compare the osseoinductive qualities of RGD coated to this new SAMP-platform (RGD/SAMP) and RGD coated to a conventional gold platform (RGDC/Au). In agreement with previous reports we found a statistical significant increased osseointegration over time at eight weeks. We did not find a difference in push-out force between the two different coatings.