Department Accomplishments

Faculty Awards

Edward B. Leof, Ph.D.
Professor, Biochemistry, Molecular Biology and Medicine

Merit award from the National Institute of General Medical Sciences (NIGMS)

Dr. Leof's research interest focuses on transforming growth factor-ß; and its downstream pathways that contribute to cellular processes in cancer, fibrotic disorders, immune modulation, and wound healing.

Peter C. Harris, Ph.D.
Professor, Biochemistry, Molecular Biology and Medicine

Homer Smith Award from the American Society of Nephrology

Rajiv Kumar, M.D.
Professor, Biochemistry, Molecular Biology and Medicine

Louis V. Avioli Founders Award from the American Society of Bone and Mineral Metabolism

Publications

• Pan S, Chen HH, Dickey DM, Boerrigter G, Lee C, Kleppe LS, Hall JL, Lerman A, Redfield MM, Potter LR, Burnett JC Jr, Simari RD. Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide. Proc Natl Acad Sci U S A, 2009 Jun 18. [Epub ahead of print]
• Owen BA, H Lang W, McMurray CT. The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent. Nat Struct Mol Biol, 2009 May; 16(5):550-7.
• Wilkes MC, Repellin CE, Hong M, Bracamonte M, Penheiter SG, Borg JP, Leof EB. Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta. Dev Cell, 2009 Mar; 16(3):433-44.
• Malureanu LA, Jeganathan KB, Hamada M, Wasilewski L, Davenport J, van Deursen JM. BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase. Dev Cell, 2009 Jan; 16(1):118-31.
• Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Proc Natl Acad Sci U S A, 2008 Dec; 105(52):20764-9.
• Nolz JC, Nacusi LP, Segovis CM, Medeiros RB, Mitchell JS, Shimizu Y, Billadeau DD. The WAVE2 complex regulates T cell receptor signaling to integrins via Abland CrkL-C3G-mediated activation of Rap1. J Cell Biol, 2008 Sep; 182(6):1231-44.
• Li Q, Zhou H, Wurtele H, Davies B, Horazdovsky B, Verreault A, Zhang Z. Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly.[see comment]. Cell, 2008 Jul; 134(2):244-55.
• Baker DJ, Perez-Terzic C, Jin F, Pitel K, Niederlander NJ, Jeganathan K, Yamada S, Reyes S, Rowe L, Hiddinga HJ, Eberhardt NL, Terzic A, van Deursen JM. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol, 2008 Jul; 10(7):825-36.
• Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM. Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell, 2008 Apr; 133(1):103-15.