OVERVIEW

Researchers in our lab are using modern molecular and biochemical methods to identify the mechanisms causing brain degeneration that are most likely to be impacted by new drug therapies.

Using molecular approaches, we are trying to identify and develop potential new drugs for Alzheimer's disease and Krabbe disease.

Work in our laboratory is focused on using modern molecular and biochemical methods to elucidate those pathways involved in neurodegenerative disease that are most amenable to therapeutic intervention.

Using both small molecule libraries and molecular approaches we then seek to identify and develop potential lead therapeutics. Current work in the group is focused on Alzheimer's disease and on Krabbe disease.

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder in the elderly affecting millions of individuals throughout the world. A pathological hallmark of AD is the presence of extracellular protein deposits referred to as senile plaques. The predominant proteinaceous component of these plaques is a self-aggregating peptide known as β amyloid (Aβ).

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